The only time that the Arizona Coyotes drafted 50th overall was during the 2004 Draft, where they selected Russian winger Enver Lisin. Lisin ultimately spent three years with the Coyotes and according to an old Sarah McLellan article, was called Webster in the locker room because, according to Shane Doan, "[h]e knows everything, supposedly."
How the Coyotes, acquired this pick is actually a pretty long and convoluted story. The pick was originally a compensation pick for the Dallas Stars who had lost Derian Hatcher. Dallas then sent the pick along with prospect Drew Bagnall to Florida in March in order to get Valeri Bure. On the first day of the 2004 draft Florida traded the 50th pick and their 73rd to the Rangers in order to get the 37th pick, which was originally theirs but they had previously traded to Denver along with Peter Worrell in order to get Eric Messier and Vaclav Nedorost. Phoenix then traded the 60th pick and the 80th pick, which had originally belonged to the Philadelphia Flyers and Edmonton Oilers respectively, to New York in exchange for the 50th pick. The Coyotes acquired Philadelphia's pick in a trade the previous year sending Tony Amonte to Philadelphia in exchange for Guillaume Lefebvre and the pick and they acquired Edmonton's pick in a scenario that is more complicated than this one so we are just going to skip it because this is complicated enough as it is.
[Author's note: If you are anything like me and like to get sucked down that rabbit hole that is pick trading, I highly recommend looking into this one. This was a good summary of how the Coyotes acquired this pick however the list of things that had to happen in order for Phoenix to acquire this pick is fairly large and worth checking out if you want to lose an hour of your life.]
Lisin started his NHL career with the Coyotes during the 2006-07 season which also saw him spend time with the RSL's Ak Bars Kazan and the AHL's San Antonio Rampage. His first year saw him play 17 games and finish 1-1-2 in a season where the Coyotes were the worst team in the Western Conference. He spent the next year mostly in the AHL with the Rampage, however he did seem to be improving as his 13 NHL games in 2007-08 saw him finish 4-1-5. The 2008-09 was the first season where he spent a majority of his time in NHL. After 48 games, he was 13-8-21 which made him 10th among Coyotes' skaters ahead of players like Kyle Turris and Derek Morris.
The Coyotes traded Lisin to the New York Rangers on July 13, 2009 for Lauri Korpikoski who has played with the team ever since. He would play one more season with the Rangers where he went 6-8-14 before returning to Russia and playing in the KHL with the Mellurg Magnitogorsk and later the Vladivostok Admiral and CSKA Moscow teams.